Download Chemical Synthesis of Nucleoside Analogues by Pedro Merino PDF

By Pedro Merino

Compiles present verified and confirmed ways to synthesize novel nucleoside analogues

Featuring contributions from top artificial chemists from around the globe, this e-book brings jointly and describes demonstrated and confirmed ways for the chemical synthesis of universal households of nucleoside analogues. Readers will learn how to create new nucleoside analogues with wanted healing homes by utilizing various tips on how to chemically regulate normal nucleosides, including:

  • Changes to the heterocyclic base
  • Modification of substituents on the sugar ring
  • Replacement of the furanose ring by way of a special carbo- or heterocyclic ring
  • Introduction of conformational restrictions
  • Synthesis of enantiomers
  • Preparation of hydrolitically solid C-nucleosides

Chemical Synthesis of Nucleoside Analogues covers all of the significant periods of nucleosides, together with pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers that have proven nice promise as beginning issues for the synthesis of nucleoside analogues. The e-book additionally comprises experimental techniques for key reactions concerning the synthesis of nucleoside analogues, delivering a worthwhile instrument for the training of a few diversified compounds.

Throughout the e-book, chemical schemes and figures aid readers larger comprehend the chemical buildings of nucleoside analogues and the tools used to synthesize them. broad references function a gateway to the growing to be physique of unique learn reports and experiences within the field.

Synthetically converted nucleosides have confirmed their worth as healing medications, specifically as antiviral and antitumor brokers. even if, a lot of those nucleoside analogues have bad uncomfortable side effects. With Chemical Synthesis of Nucleoside Analogues as their consultant, researchers have a brand new device for synthesizing a brand new new release of nucleoside analogues that may be used as healing medications with fewer undesirable part effects.

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